Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study.

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Version: Final published version
Serval ID
serval:BIB_351FC3E8D28B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study.
Journal
International journal of environmental research and public health
Author(s)
Jeannot E., Viviano M., de Pree C., Amadane M., Kabengele E., Vassilakos P., Petignat P.
ISSN
1660-4601 (Electronic)
ISSN-L
1660-4601
Publication state
Published
Issued date
09/07/2018
Peer-reviewed
Oui
Volume
15
Number
7
Pages
1447
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Background: The human papillomavirus (HPV) vaccination program for young girls aged 11⁻26 years was introduced in Switzerland in 2008. The objective of this study was to evaluate the prevalence of high- and low-risk HPV in a population of undergraduate students using self-sampling for monitoring the HPV vaccination program's effect.
Undergraduate women aged between 18⁻31 years, attending the Medical School and University of Applied Sciences in Geneva, were invited to participate in the study. Included women were asked to perform vaginal self-sampling for HPV testing using a dry cotton swab.
A total of 409 students participated in the study-aged 18⁻31 years-of which 69% of the participants were vaccinated with Gardasil HPV vaccine and 31% did not received the vaccine. About HPV prevalence, 7.2% of unvaccinated women were HPV 16 or 18 positive, while 1.1% of vaccinated women were infected by HPV 16 or 18 (p < 0.01). Prevalence of HPV 6 and 11 was 8.3% in non-vaccinated women versus 2.1% in vaccinated women (p < 0.02). We observed no cross-protection for the other HPV genotypes of a low- and high-risk strain.
Prevalence of HPV 6/11/16/18 was lower in vaccinated women versus unvaccinated women. Continued assessment of HPV vaccine effectiveness in real population is needed.
Keywords
Adolescent, Adult, Female, Human papillomavirus 16/isolation & purification, Human papillomavirus 18/isolation & purification, Humans, Immunization, Papillomavirus Infections/epidemiology, Papillomavirus Infections/prevention & control, Papillomavirus Vaccines/administration & dosage, Prevalence, Sampling Studies, Switzerland/epidemiology, Vaccination, Young Adult, HPV, self-sampling, vaccination
Pubmed
Web of science
Open Access
Yes
Create date
24/07/2018 12:48
Last modification date
20/08/2019 14:22
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