Spontaneous Aberrant Bodies Formation in Human Pneumocytes Infected with Estrella lausannensis.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_34EFA3AE06FC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Spontaneous Aberrant Bodies Formation in Human Pneumocytes Infected with Estrella lausannensis.
Journal
Microorganisms
Author(s)
Rovero A., Kebbi-Beghdadi C., Greub G.
ISSN
2076-2607 (Print)
ISSN-L
2076-2607
Publication state
Published
Issued date
22/09/2023
Peer-reviewed
Oui
Volume
11
Number
10
Pages
2368
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Estrella lausannensis, a Chlamydia-related bacterium isolated from a Spanish river, is considered as a possible emerging human pathogen. Indeed, it was recently demonstrated to multiply in human macrophages, resisting oxidative burst and causing a strong cytopathic effect. In addition, a preliminary study highlighted a correlation between antibody response to E. lausannensis and pneumonia in children. To clarify the pathogenic potential of these bacteria, we infected a human pneumocyte cell line with E. lausannensis and assessed its replication and cytopathic effect using quantitative real-time PCR and immunofluorescence, as well as confocal and electron microscopy. Our results demonstrated that E. lausannensis enters and replicates rapidly in human pneumocytes, and that it causes a prompt lysis of the host cells. Furthermore, we reported the spontaneous formation of aberrant bodies, a form associated with persistence in Chlamydiae, suggesting that E. lausannensis infection could cause chronic disorders in humans.
Keywords
Chlamydia-related bacterium, chronic infection, cytopathic effect, persistence, replication
Pubmed
Web of science
Open Access
Yes
Create date
06/11/2023 12:29
Last modification date
08/08/2024 7:31
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