Inflammation, immunity, vaccines for Helicobacter infection

Details

Serval ID
serval:BIB_34CED91896B6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Inflammation, immunity, vaccines for Helicobacter infection
Journal
Helicobacter
Author(s)
Chmiela  M., Michetti  P.
ISSN
1083-4389 (Print)
Publication state
Published
Issued date
10/2006
Volume
11 Suppl 1
Pages
21-6
Notes
Journal Article
Review --- Old month value: Oct
Abstract
The reason why some individuals remain Helicobacter pylori infected for life but without any symptoms while others develop severe diseases is only partially clarified. Presumably, it depends on multifactorial interactions among host immunologic and physiologic factors, bacterial virulence determinants, and environmental influences modulating the host response. Much effort has been made to identify host genetic factors that may explain an individual susceptibility of the host to H. pylori infection. The identification of H. pylori determinants and the elucidation of their role in modifying the host immune responses were further delineated. The ability of H. pylori to overcome the defense mechanisms on mucosal surfaces as well as to modulate the immune response by interfering with host recognition and transduction systems has been shown. Also new bacterial anti-inflammatory defense systems have been described. Findings in experimental animal models and humans with natural H. pylori infection suggested a double role of regulatory T cells in the course of H. pylori infection: protecting the infected host against excessive gastric inflammation and, in contrast, promoting bacterial colonization.
Keywords
Animals *Bacterial Vaccines/immunology/therapeutic use Cell Line Gastric Mucosa/*immunology/microbiology Helicobacter Infections/*immunology/microbiology/physiopathology/prevention & control Helicobacter pylori/*immunology/pathogenicity Humans Inflammation/*immunology/microbiology/physiopathology Mice
Pubmed
Web of science
Create date
25/01/2008 16:02
Last modification date
20/08/2019 13:21
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