Roles of exosomes in cardioprotection.

Details

Serval ID
serval:BIB_34B794B22FFA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Roles of exosomes in cardioprotection.
Journal
European heart journal
Author(s)
Barile L., Moccetti T., Marbán E., Vassalli G.
ISSN
1522-9645 (Electronic)
ISSN-L
0195-668X
Publication state
Published
Issued date
07/05/2017
Peer-reviewed
Oui
Volume
38
Number
18
Pages
1372-1379
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Exosomes are extracellular vesicles of endosomal origin which have emerged as key mediators of intercellular communication. All major cardiac cell types-including cardiomyocytes, endothelial cells, and fibroblasts-release exosomes that modulate cellular functions. Exosomes released from human cardiac progenitor cells (CPCs) are cardioprotective and improve cardiac function after myocardial infarction to an extent comparable with that achieved by their parent cells. Cardiac progenitor cell-derived exosomes are enriched in cardioprotective microRNAs, particularly miR-146a-3p. Circulating exosomes mediate remote ischaemic preconditioning. Moreover, they currently are being investigated as diagnostic markers. The discovery that cell-derived extracellular signalling organelles mediate the paracrine effects of stem cells suggests that cell-free strategies could supplant cell transplantation. This review discusses emerging roles of exosomes in cardiovascular physiology, with a focus on cardioprotective activities of CPC-derived exosomes.

Keywords
Biomarkers/metabolism, Cardiovascular Diseases/physiopathology, Endothelial Cells/secretion, Exosomes/physiology, Exosomes/secretion, Humans, Ischemic Preconditioning, Myocardial/methods, Myoblasts, Cardiac/secretion, Myocytes, Cardiac/physiology, Myocytes, Cardiac/secretion, Stem Cells/secretion, Cardioprotection, Exosomes, Progenitor cells
Pubmed
Web of science
Open Access
Yes
Create date
08/12/2016 14:14
Last modification date
20/08/2019 13:21
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