Immune-Mediated Liver Disease in the Transplanted Liver

Details

Serval ID
serval:BIB_348144585B4E
Type
A part of a book
Publication sub-type
Chapter: chapter ou part
Collection
Publications
Institution
Title
Immune-Mediated Liver Disease in the Transplanted Liver
Title of the book
Liver Immunology
Author(s)
Vionnet Julien, Sanchez-Fueyo Alberto, Neuberger James
Publisher
Springer International Publishing
ISBN
9783030517083
9783030517090
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Chapter
36
Pages
597-620
Edition
3e édition
Language
english
Abstract
Liver transplantation has evolved as the treatment of choice for many patients with end-stage liver disease. Currently, survival posttransplant is excellent, with 10-year survival exceeding 65%. Causes of graft failure include recurrent disease, in particular autoimmune disease, alcoholic liver disease, and NAFLD. Immune-mediated injury is also a cause for graft failure, but this cause has proved to be less common nowadays. With the actual range of potent immunosuppressive agents and a greater use of a tailored approach, rejection is seen less frequently. Rejection may take the form of T-cell-mediated rejection (TCMR), antibody-mediated rejection (AMR), and plasma cell-rich hepatitis. On the opposite end of the spectrum, operational tolerance develops in a small proportion of liver transplant recipients. Finally, as indicated earlier, some autoimmune diseases can recur in the allograft.
Create date
27/12/2021 12:49
Last modification date
28/12/2021 7:37
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