This article presents a selection of ten key topics, carefully analyzed and commented on by chief residents at the Department of Internal Medicine at CHUV. This curated selection highlights the major advances and essential reminders in internal medicine for 2024. By reviewing this year's leading publications, it sheds light on progress in diagnostic and therapeutic approaches, both for hospitalized patients and the continuity of care in outpatient settings. From diabetes to cardiology, including gender medicine and nephrology, each area is examined with a focus on clinical innovations. This retrospective provides practitioners with a valuable resource to stay up to date with the latest developments, helping to improve the quality of care delivered to patients.