Neutrophil phenotypes and functions in cancer: A consensus statement.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_34420E8CFB04
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Neutrophil phenotypes and functions in cancer: A consensus statement.
Journal
The Journal of experimental medicine
Author(s)
Quail D.F., Amulic B., Aziz M., Barnes B.J., Eruslanov E., Fridlender Z.G., Goodridge H.S., Granot Z., Hidalgo A., Huttenlocher A., Kaplan M.J., Malanchi I., Merghoub T., Meylan E., Mittal V., Pittet M.J., Rubio-Ponce A., Udalova I.A., van den Berg T.K., Wagner D.D., Wang P., Zychlinsky A., de Visser K.E., Egeblad M., Kubes P.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
06/06/2022
Peer-reviewed
Oui
Volume
219
Number
6
Pages
e20220011
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
Keywords
Humans, Immunity, Innate, Inflammation, Neoplasms/genetics, Neutrophils, Phenotype
Pubmed
Web of science
Open Access
Yes
Create date
17/05/2022 12:27
Last modification date
01/04/2023 5:51
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