Association of IBD specific treatment and prevalence of pain in the Swiss IBD cohort study.

Details

Ressource 1Download: BIB_34368FCA2A28.pdf (555.17 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_34368FCA2A28
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association of IBD specific treatment and prevalence of pain in the Swiss IBD cohort study.
Journal
PloS one
Author(s)
Bon L., Scharl S., Vavricka S., Rogler G., Fournier N., Pittet V., Scharl M., Greuter T., Schreiner P., Frei P., Misselwitz B., Biedermann L., Zeitz J.
Working group(s)
Swiss IBD Cohort Study Group
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
14
Number
4
Pages
e0215738
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Extraintestinal manifestations (EIM) contribute significantly to the burden of disease in inflammatory bowel disease (IBD). Pain is a leading symptom in IBD and could be seen as an EIM itself. Treatment of IBD associated pain is challenging and insufficiently studied. A better knowledge on the association of pain and IBD specific treatment is warranted to improve the management of IBD patients.
All patients of the Swiss IBD Cohort Study (SIBDCS) (n = 2152) received a questionnaire regarding pain localization, pain character, and the use of IBD specific medication.
1263 completed questionnaires were received. Twenty-one out of 184 patients (10%) receiving anti-TNF treatment compared to 142 out of 678 patients (21%) not receiving anti-TNF medication reported elbow pain (p = 0.002) while 28 out of 198 patients (14%) receiving steroid treatment significantly more often reported elbow pain compared to 59 from 696 patients (8%) not receiving steroids (p = 0.021). Furthermore, we found significantly more female patients under anti-TNF treatment to report knee/ lower leg pain and ankle/ foot pain compared to their male counterparts (36% vs. 20% and 22% vs. 10%, respectively, p = 0.015 for both comparisons). The frequency of knee, lower leg, ankle and foot pain was especially low in male patients under anti-TNF treatment, indicating a high benefit of male patients from anti-TNF therapy regarding EIM.
The frequency of elbow pain was lower in IBD patients treated with anti-TNF but higher in patients treated with steroids.
Keywords
Anti-Inflammatory Agents/pharmacology, Anti-Inflammatory Agents/therapeutic use, Arthralgia/epidemiology, Arthralgia/etiology, Arthralgia/prevention & control, Elbow Joint, Female, Follow-Up Studies, Foot Joints, Humans, Inflammatory Bowel Diseases/complications, Inflammatory Bowel Diseases/drug therapy, Inflammatory Bowel Diseases/immunology, Knee Joint, Male, Middle Aged, Prevalence, Prospective Studies, Risk Factors, Sex Factors, Switzerland/epidemiology, Treatment Outcome, Tumor Necrosis Factor-alpha/antagonists & inhibitors, Tumor Necrosis Factor-alpha/immunology
Pubmed
Web of science
Open Access
Yes
Create date
09/05/2019 13:01
Last modification date
18/02/2020 6:20
Usage data