Expanding the therapeutic index of radiation therapy by normal tissue protection.

Details

Serval ID
serval:BIB_33F51A1C2CCF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Expanding the therapeutic index of radiation therapy by normal tissue protection.
Journal
The British journal of radiology
Author(s)
Montay-Gruel P., Meziani L., Yakkala C., Vozenin M.C.
ISSN
1748-880X (Electronic)
ISSN-L
0007-1285
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
92
Number
1093
Pages
20180008
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Normal tissue damages induced by radiation therapy remain dose-limiting factors in radiation oncology and this is still true despite recent advances in treatment planning and delivery of image-guided radiation therapy. Additionally, as the number of long-term cancer survivors increases, unacceptable complications emerge and dramatically reduce the patients' quality of life. This means that patients and clinicians expect discovery of new options for the therapeutic management of radiation-induced complications. Over the past four decades, research has enhanced our understanding of the pathophysiological, cellular and molecular processes governing normal tissue toxicity. Those processes are complex and involve the cross-talk between the various cells of a tissue, including fibroblasts, endothelial, immune and epithelial cells as well as soluble paracrine factors including growth factors and proteases. We will review the translatable pharmacological approaches that have been developed to prevent, mitigate, or reverse radiation injuries based upon the targeting of cellular and signalling pathways. We will summarize the different steps of the research strategy, from the definition of initial biological hypotheses to preclinical studies and clinical translation. We will also see how novel research and therapeutic hypotheses emerge along the way as well as briefly highlight innovative approaches based upon novel radiotherapy delivery procedures.
Keywords
Animals, Cell Death/radiation effects, Dose-Response Relationship, Radiation, Humans, Neoplasms/pathology, Neoplasms/radiotherapy, Oxidation-Reduction/drug effects, Patient Safety, Proton Therapy/adverse effects, Proton Therapy/methods, Radiation Injuries/prevention & control, Radiotherapy/adverse effects, Radiotherapy/methods, Radiotherapy, Image-Guided/methods, Reference Values
Pubmed
Web of science
Create date
26/04/2018 16:36
Last modification date
26/06/2020 5:21
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