Inflammatory Response and Toxicity After Pressurized IntraPeritoneal Aerosol Chemotherapy.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_33E75BC4D4BC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inflammatory Response and Toxicity After Pressurized IntraPeritoneal Aerosol Chemotherapy.
Journal
Journal of Cancer
Author(s)
Teixeira Farinha H., Grass F., Labgaa I., Pache B., Demartines N., Hübner M.
ISSN
1837-9664 (Print)
ISSN-L
1837-9664
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
13-20
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Background: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel mode of intraperitoneal (IP) drug delivery claiming high IP tissue concentrations with low systemic uptake. The aim was to study inflammatory response and systemic toxicity after PIPAC. Methods: Retrospective monocentric analysis of a consecutive cohort of PIPAC patients between January 2015 and April 2016. Detailed hematological and biochemical analysis was performed the day before surgery and once daily until discharge. Comparative statistics were performed using Mann-Whitney U test and Wilcoxon signed ranked test. Results: Fourty-two consecutive patients underwent a total of 91 PIPAC procedures. Twenty patients received oxaliplatin and 22 cisplatin+doxorubicin (37 vs. 54 procedures). Creatinine, AST and ALT were not significantly altered after PIPAC (p=0.095, p= p=0.153 and p=0.351) and not different between oxaliplatin and cisplatin+doxorubicin regimens (p=0.371, p=0.251 and p=0.288). C-reactive protein (CRP) and procalcitonin (PCT) increased on post-operative day (POD) 2: ∆max 29±5 mg/L (p<0.001) and ∆max 0.05±0.01 μg/L (p=0.005), respectively. Leucocytes increased at POD 1: ∆max 2.2±0.3 G/L (p<0.001). Albumin decreased at POD 2: ∆max -6.0±0.5 g/L (p<0.001). CRP increase correlated positively with Peritoneal Cancer Index (tumor load) (ρ =0.521, p<0.001). Conclusion: PIPAC was followed by a modest and transitory inflammatory response that was commensurate to the disease extent. No hematological, renal or hepatic toxicity was observed even after repetitive administration.

Keywords
Intraperitoneal Chemotherapy, PIPAC, Peritoneal Carcinomatosis, Toxicity
Pubmed
Web of science
Open Access
Yes
Create date
08/01/2018 18:08
Last modification date
20/08/2019 14:20
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