Le système rénine-angiotensine dans le cerveau humain et les tumeurs cérébrales: une fonction autre que la régulation de la pression? [The renin-angiotensin system in human brain and brain tumors: a function unrelated to blood pressure control?]

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_339CF6F70A24
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Le système rénine-angiotensine dans le cerveau humain et les tumeurs cérébrales: une fonction autre que la régulation de la pression? [The renin-angiotensin system in human brain and brain tumors: a function unrelated to blood pressure control?]
Journal
Bulletin de l'Academie nationale de medecine
Author(s)
Juillerat-Jeanneret L., Gasc J.M., Corvol P.
ISSN
0001-4079 (Print)
ISSN-L
0001-4079
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
188
Number
4
Pages
639-46; discussion 647-8
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
The renin-angiotensin system (RAS), in addition to controlling blood pressure and the sodium-water balance, may be involved in cell growth and/or death in the brain. In order to address this issue, we compared the expression of RAS components in surgical specimens of human brain tumors and adjacent tissue. Human brain tumor cells and rat brain cells in culture were used to evaluate RAS functions. We found evidence that the RAS may be involved in maintaining the functions of the cerebral vasculature (the blood-brain-barrier) by controlling the ratio between angiotensin II and angiotensin III production, and by playing a more direct role in the survival of astroglial cells.
Keywords
Angiotensin II/pharmacokinetics, Angiotensin II/pharmacology, Angiotensin III/pharmacokinetics, Angiotensin III/pharmacology, Animals, Apoptosis, Blood Pressure/physiology, Blood-Brain Barrier, Brain/blood supply, Brain/physiology, Brain Neoplasms/physiopathology, Cell Proliferation, Cell Survival, Humans, Neoplasms, Experimental, Rats, Renin-Angiotensin System/physiology, Vasoconstrictor Agents/pharmacokinetics, Vasoconstrictor Agents/pharmacology
Pubmed
Web of science
Create date
29/01/2008 19:34
Last modification date
18/07/2020 6:19
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