Response of babesiosis to pentamidine therapy
Details
Serval ID
serval:BIB_337D60988A48
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Response of babesiosis to pentamidine therapy
Journal
Annals of Internal Medicine
ISSN
0003-4819 (Print)
Publication state
Published
Issued date
03/1981
Volume
94
Number
3
Pages
326-30
Notes
Case Reports
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar
Abstract
Three nonsplenectomized patients were infected with Babesia microti. One had fever, abdominal pain suggesting gallbladder disease, and evidence of disseminated intravascular coagulation; another was considered to have lymphoma, partly because two smears for Babesia before admission were negative. All three patients were treated with pentamidine isethionate and improved clinically. Parasites were no longer seen on smears after 5 days of therapy, but Babesia could still be recovered by hamster inoculation 5 weeks after therapy in one of the patients tested, underscoring the need for this test to properly evaluate eradication of the organism. In one patient, pentamidine was stopped after 7 days because of increased creatinine concentration, and this amount of drug appeared adequate to control the parasitemia. Pain at drug injection sites was a major side effect in all three patients. Pentamidine appears to be useful in controlling clinical manifestations of babesiosis and decreasing parasitemia, but it does not eradicate the organism.
Keywords
Aged
Amidines/*therapeutic use
Animals
Babesia/isolation & purification
Babesiosis/*drug therapy/parasitology/pathology
Female
Humans
Male
Middle Aged
Pain/chemically induced
Pentamidine/adverse effects/*therapeutic use
Splenectomy
Time Factors
Pubmed
Web of science
Create date
25/01/2008 17:07
Last modification date
20/08/2019 13:19