What is the most relevant standard of success in assisted reproduction?: The cumulated singleton/twin delivery rates per oocyte pick-up: the CUSIDERA and CUTWIDERA.

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_33707
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
What is the most relevant standard of success in assisted reproduction?: The cumulated singleton/twin delivery rates per oocyte pick-up: the CUSIDERA and CUTWIDERA.
Journal
Human Reproduction
Author(s)
Germond M., Urner F., Chanson A., Primi M.P., Wirthner D., Senn A.
ISSN
0268-1161 (Print)
ISSN-L
0268-1161
Publication state
Published
Issued date
2004
Volume
19
Number
11
Pages
2442-2444
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
National and international registries are essential tools for establishing new standards and comparing success rates, but they do not take into account the total pregnancy/delivery rate per oocyte recovery. In Switzerland and Germany, because of legal constraints, a maximum of three two-pronuclear zygotes are allocated for transfer whereas all the supernumerary pronuclear zygotes are immediately cryopreserved, preventing selection of the transferred embryos. We report on a 10 years' experience (1993-2002) of our centre which performs transfers of unselected embryos and cryopreservation at the two-pronuclear zygote stage. As approximately 30% of all deliveries are from cryo cycles, it is essential to take into account the contribution of the cryo transfers, and we propose therefore to evaluate, as a measure of IVF performance, the cumulated delivery rate per oocyte pick-up. This delivery rate is broken down further into the cumulated singleton delivery rate (CUSIDERA) and the cumulated twin delivery rate (CUTWIDERA). The sum (S) of these two rates is a measure of efficacy while the ratio CUTWIDERA/S as a percentage is a measure of safety of IVF treatments. Using these new indexes, the average 10 year efficacy and safety of our IVF programme were 26 and 19%, respectively. Both CUSIDERA and CUTWIDERA can be calculated easily in any clinical situation and yield useful parameters for patient counselling and internal/external benchmarking purposes.
Keywords
Cryopreservation/methods, Delivery, Obstetric/statistics & numerical data, Embryo Transfer, Female, Fertilization in Vitro/statistics & numerical data, Humans, Oocytes/physiology, Pregnancy, Reproductive Techniques, Assisted/standards, Reproductive Techniques, Assisted/statistics & numerical data, Treatment Outcome, Twins
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 11:04
Last modification date
25/09/2019 7:08
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