Facilitators and barriers of women's participation in HIV clinical research in Switzerland: A qualitative study.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_3347FF6BD468
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Facilitators and barriers of women's participation in HIV clinical research in Switzerland: A qualitative study.
Journal
HIV medicine
Author(s)
Courvoisier N., Storari C., Lesage S., Vittoz L., Barbieux C., Peytremann-Bridevaux I., Gilles I., Calmy A.
ISSN
1468-1293 (Electronic)
ISSN-L
1464-2662
Publication state
Published
Issued date
04/2022
Peer-reviewed
Oui
Volume
23
Number
4
Pages
441-447
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Women are underrepresented in most HIV clinical trials in Western countries, but their participation remains crucial as the lack of information on sex- and gender-specific effects may hinder the safety and efficacy of antiretroviral treatments. The aim of this study was to identify barriers to and facilitators of women's participation in HIV clinical trials in Switzerland.
We conducted semi-structured interviews among 20 women with HIV to explore factors associated with non-participation in clinical trials. The interviewer presented to participants a clinical trial's description and discussed it with them. Lexicometric analysis on transcribed interviews identified three themes and eight sub-themes related to the pros and cons of participation in HIV clinical trials.
Participants evoked mainly decision-making drivers, concerns for women living with HIV and treatment side-effects. They highlighted the need for extensive information provided by trusted healthcare professionals on the research process as central to the decision to enrol in HIV clinical trials. Familial responsibilities were clearly identified as barriers to their participation, but not pregnancy. Additional preoccupations were other health concerns and comorbidities and the consequences of stopping ongoing antiretroviral treatments.
To overcome the barriers to the participation of women living with HIV in clinical research in Western countries, healthcare professionals and researchers should increase women's research literacy by involving them in the study design and by tailoring clinical trials to their social roles and health concerns. Trust in professionals is a facilitator of enrolment of women living with HIV that should be maintained.
Keywords
Anti-Retroviral Agents/therapeutic use, Female, HIV Infections/drug therapy, Health Personnel, Humans, Pregnancy, Qualitative Research, Switzerland, HIV clinical trial, HIV women, gender perspective, people living with HIV, qualitative research
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2022 10:59
Last modification date
09/08/2022 6:09
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