Image-guided percutaneous cryoablation of unresectable sacrococcygeal chordoma: Feasibility and outcome in a selected group of patients with long term follow-up.

Details

Serval ID
serval:BIB_3341523072BD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Image-guided percutaneous cryoablation of unresectable sacrococcygeal chordoma: Feasibility and outcome in a selected group of patients with long term follow-up.
Journal
Journal of surgical oncology
Author(s)
Cherix S., Traverso A., Bazan A.A., Gallusser N., Heutschi-Ozturk H., Abou-Khalil S., Goetti P., Letovanec I., Montemurro M., Bize P.
ISSN
1096-9098 (Electronic)
ISSN-L
0022-4790
Publication state
Published
Issued date
04/11/2020
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Chordoma is a rare malignant tumor of the axial skeleton. Percutaneous cryoablation (PCA) is a minimally invasive technique that allows freezing of tumors under imaging control. The purpose of our retrospective study was to investigate the outcome of PCA in a selected cohort of patients with sacrococcygeal chordoma, with a minimum of 5 years follow-up.
Four patients were treated in 10 sessions. The mean follow-up was 57.3 months. We evaluated the feasibility, the procedure-related complications, the impact on pain control and oncological outcomes.
Freezing of 100% of the tumor volume was possible in 60%. Pain control was not reliably evaluable. Local recurrence occurred in 90% of the treated lesions; the mean time to progression was 8.1 months (range 1.5-16). At last follow-up, one patient had died of the disease, one of another cause and one was receiving the best supportive care. The only patient alive without the disease had received additional carbon-ion radiotherapy. The 5-year survival rate after index PCA was 50%.
Complete freezing of the tumor was technically challenging, mainly due to the complex local anatomy. Recurrence occurred in 90% of the lesions treated. PCA should be considered with caution in the curative management of sacrococcygeal chordoma.
Keywords
percutaneous cryoablation, sacrococcygeal chordoma
Pubmed
Web of science
Create date
05/11/2020 13:16
Last modification date
22/12/2020 6:25
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