Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism.

Details

Serval ID
serval:BIB_333ACF56385B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism.
Journal
Frontiers in endocrinology
Author(s)
Mercorio A., Giampaolino P., Romano A., Dällenbach P., Pluchino N.
ISSN
1664-2392 (Print)
ISSN-L
1664-2392
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
13
Pages
950866
Language
english
Notes
Publication types: Systematic Review
Publication Status: epublish
Abstract
Endometriosis is a chronic, multifactorial, estrogen-dependent disease. The abnormal endocrine microenvironment of endometriosis lesions is considered a main feature and multiple enzymatic pathways leading to local increased synthesis of estrogens have been identified. However, the relevance of intracrinology in clinical practice is still lacking. Medline, Embase, Scopus database were systematically searched for studies reporting on local estrogens metabolism of endometriotic lesions. The main enzymatic pathways involved in the intracrinology of endometriosis such as aromatase (CYP19A1), 17β-hydroxysteroid dehydrogenase (HSD17B) type 1, type 2 and type 5, steroid sulfatase (STS), estrogen sulfotransferase (SULT1E1) were assessed with a critical perspective on their role in disease endocrine phenotyping, drug resistance and as therapeutic targets. Overall, studies heterogeneity and missing clinical data affect the interpretation of the clinical role of these enzymes. Although the use of some drugs such as aromatase inhibitors has been proposed in clinical practice for two decades, their potential clinical value is still under investigation as well as their modality of administration. A closer look at new, more realistic drug targets is provided and discussed. Altered expression of these key enzymes in the lesions have far reaching implication in the development of new drugs aimed at decreasing local estrogenic activity with a minimal effect on gonadal function; however, given the complexity of the evaluation of the expression of the enzymes, multiple aspects still remains to be clarified.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022311329, identifier CRD42022311329.
Keywords
Aromatase/metabolism, Aromatase Inhibitors/therapeutic use, Endometriosis/metabolism, Estrogens/metabolism, Female, Humans, Steryl-Sulfatase/metabolism, endometriosis, endometrium, estrogen, metabolism, pelvic pain
Pubmed
Web of science
Open Access
Yes
Create date
15/09/2023 12:24
Last modification date
27/09/2023 13:24
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