The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease

Details

Serval ID
serval:BIB_3336AB119867
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease
Journal
Clinical Endocrinology
Author(s)
Gaillard  R. C., Grossman  A., Smith  R., Rees  L. H., Besser  G. M.
ISSN
0300-0664 (Print)
Publication state
Published
Issued date
05/1981
Volume
14
Number
5
Pages
471-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Thirteen patients with either Addison's disease, or Cushing's disease treated by bilateral adrenalectomy, were infused with the long-acting met-enkephalin analogue DAMME. In patients with Addison's disease significant and pronounced falls in ACTH and N- and C-terminal beta-LPH were seen; chromatography suggested that beta-endorphin fell concomitantly. Three out of four patients with Cushing's disease who had not received pituitary irradiation, also showed a decrease in plasma ACTH and N- and C-terminal beta-LPH; however, no change was seen in any of the irradiated patients. The changes were naloxone reversible. The levels of plasma met-enkephalin were normal and did not change after DAMME in any group of patients. These results are interpreted as suggesting that there are inhibitory opiate receptors controlling the release of ACTH, beta-LPH, and beta-endorphin.
Keywords
Addison Disease/*physiopathology Adrenalectomy Adrenocorticotropic Hormone/*secretion Adult Cushing Syndrome/*physiopathology D-Ala(2),MePhe(4),Met(0)-ol-enkephalin Endorphins/*diagnostic use/secretion Enkephalin, Methionine Enkephalins/*diagnostic use/secretion Female Hormones/*diagnostic use Humans Male Middle Aged Naloxone/diagnostic use beta-Endorphin beta-Lipotropin/*secretion
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 13:19
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