EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry.

Details

Serval ID
serval:BIB_3336A82967EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry.
Journal
BMJ open
Author(s)
Nordanstig A., Curtze S., Gensicke H., Zinkstok S.M., Erdur H., Karlsson C., Karlsson J.E., Martinez-Majander N., Sibolt G., Lyrer P., Traenka C., Baharoglu M.I., Scheitz J.F., Bricout N., Hénon H., Leys D., Eskandari A., Michel P., Hametner C., Ringleb P.A., Arnold M., Fischer U., Sarikaya H., Seiffge D.J., Pezzini A., Zini A., Padjen V., Jovanovic D.R., Luft A., Wegener S., Kellert L., Feil K., Kägi G., Rentzos A., Lappalainen K., Leker R.R., Cohen J.E., Gomori J., Brehm A., Liman J., Psychogios M., Kastrup A., Papanagiotou P., Gralla J., Magoni M., Majoie CBLM, Bohner G., Vukasinovic I., Cvetic V., Weber J., Kulcsar Z., Bendszus M., Möhlenbruch M., Ntaios G., Kapsalaki E., Jood K., Nolte C.H., Nederkoorn PJJ, Engelter S., Strbian D., Tatlisumak T.
Working group(s)
EVA-TRISP Investigators
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Publication state
Published
Issued date
09/08/2021
Peer-reviewed
Oui
Volume
11
Number
8
Pages
e042211
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry.
All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS).
Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups.
This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.
Keywords
Brain Ischemia/drug therapy, Endovascular Procedures, Extravehicular Activity, Fibrinolytic Agents/therapeutic use, Humans, Ischemic Stroke, Registries, Stroke/drug therapy, Thrombectomy, Thrombolytic Therapy, Treatment Outcome, neurology, stroke, stroke medicine
Pubmed
Web of science
Open Access
Yes
Create date
03/09/2021 20:09
Last modification date
10/12/2021 6:39
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