Effect of acetazolamide on the optic disc oxygenation in miniature pigs.
Details
Serval ID
serval:BIB_33337
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of acetazolamide on the optic disc oxygenation in miniature pigs.
Journal
Klinische Monatsblätter für Augenheilkunde
ISSN
0023-2165
Publication state
Published
Issued date
2004
Volume
221
Number
5
Pages
367-370
Language
english
Notes
Publication types: Journal Article
Abstract
BACKGROUND: The purpose of our study was to evaluate the variations of the optic disc PO (2) during normoxia and hyperoxia (100 % O (2)), before and after intravenous administration of acetazolamide. MATERIAL AND METHODS: PO (2) measurements were obtained at intervascular areas of the optic disc in 11 anaesthetized miniature pigs using oxygen-sensitive microelectrodes introduced through the vitreous cavity by a micromanipulator. PO (2) was measured continuously during 10 minutes under systemic normoxia and systemic hyperoxia. Oxygen measurements were repeated under these conditions after intravenous injection of acetazolamide (bolus of 500 mg) in 8 animals. RESULTS: In systemic hyperoxia, the optic disc PO (2) increased moderately (DeltaPO (2) = 4.7 +/- 2.5 mmHg; p < 0.001; n = 11) in parallel with systemic PaO (2). Acetazolamide led to a slow and progressive increase in the optic disc PO (2) (DeltaPO (2) = 2.1 +/- 1.7 mmHg; p > 0.1; n = 8 after 10 min, while DeltaPO (2) = 4.3 +/- 3.2 mmHg; p < 0.05; n = 8 after 30 min), in parallel with a slow and progressive increase in systemic PaCO (2). The optic disc PO (2) increased much more significantly after injection of acetazolamide under systemic hyperoxia (DeltaPO (2) = 13.3 +/- 3.1 mmHg; p < 0.001; n = 8). CONCLUSIONS: Systemic hyperoxia alone is not sufficient to increase substantially the optic disc PO (2) in miniature pigs due to a vasoconstrictor effect. Intravenous injection of acetazolamide can increase the optic disc PO (2) progressively, due to a vasodilatory effect of elevated systemic PaCO (2). The association of acetazolamide injection with systemic hyperoxia can further improve the oxygenation of the optic disc.
Keywords
Acetazolamide/pharmacology, Animals, Carbon Dioxide/blood, Carbonic Anhydrase Inhibitors/pharmacology, Injections, Intravenous, Optic Disk/blood supply, Optic Disk/drug effects, Oxygen/blood, Oxygen Consumption/drug effects, Regional Blood Flow/drug effects, Regional Blood Flow/physiology, Swine, Swine, Miniature
OAI-PMH
Pubmed
Web of science
Create date
19/11/2007 12:32
Last modification date
20/08/2019 13:19