Virological and immunological characteristics of HIV treatment failure.

Details

Serval ID
serval:BIB_3330EC65069D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Virological and immunological characteristics of HIV treatment failure.
Journal
AIDS
Author(s)
Kaufmann D., Muñoz M., Bleiber G., Fleury S., Lotti B., Martinez R., Pichler W., Meylan P., Telenti A.
ISSN
0269-9370
Publication state
Published
Issued date
08/2000
Peer-reviewed
Oui
Volume
14
Number
12
Pages
1767-74
Language
english
Notes
Publication types: Journal Article. - Old month value: Aug 18
Abstract
BACKGROUND: Resistance to antiretroviral treatment is prevalent. There is limited knowledge of the determinants of disease evolution in subjects infected with multidrug-resistant HIV (MDR-HIV). METHODS: Infectivity, replication, chemokine receptor usage, and env, gag, protease and reverse transcriptase sequence analysis was performed for MDR-HIV isolates from 14 HIV-infected individuals and compared to wild-type HIV isolates from individuals naive to antiretroviral treatment. Expression of CD45RO/RA, Ki67 and interferon-gamma and CD4 proliferative response to various antigens was determined for individuals infected with MDR-HIV and compared to that in individuals with optimal suppression of viral replication. RESULTS: Infectivity and replication are diminished for various MDR-HIV isolates, usually in the context of an increase in CD4 and CD4+CD45RA+ T-cell counts. However, a number of MDR-HIV isolates are associated with high in vivo viraemia and pronounced immunosuppression, and display in vitro levels of infectivity and replication comparable to those of wild-type strains. No specific genetic sequence or chemokine receptor usage predicted the fitness of an MDR isolate. CONCLUSIONS: Despite the biological diversity of resistant viruses and the range of host responses observed, our descriptive analysis indicates that viral factors play a role in determining the degree of immune damage observed in the context of MDR-HIV infection.
Keywords
Adult, Aged, CD4 Lymphocyte Count, Drug Resistance, Multiple/immunology, Drug Resistance, Multiple/physiology, Female, Flow Cytometry, HIV/drug effects, HIV/genetics, HIV Infections/drug therapy, HIV Infections/immunology, HIV Protease Inhibitors/pharmacology, HIV Protease Inhibitors/therapeutic use, Humans, Male, Middle Aged, Time Factors, Treatment Failure, Viral Load, Virus Replication/immunology
Pubmed
Web of science
Create date
25/01/2008 14:45
Last modification date
20/08/2019 13:19
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