The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders.

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State: Public
Version: Final published version
Serval ID
serval:BIB_332BDFADC356
Type
Article: article from journal or magazin.
Collection
Publications
Title
The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders.
Journal
BJPsych open
Author(s)
Goodday S.M., Preisig M., Gholamrezaee M., Grof P., Angst J., Duffy A.
ISSN-L
2056-4724
Publication state
Published
Issued date
04/2017
Peer-reviewed
Oui
Volume
3
Number
2
Pages
71-77
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Hypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder.
To determine whether hypomanic symptoms differentiate offspring of parents with bipolar disorder (high risk) and offspring of well parents (control) and predict the development of mood episodes.
High-risk and control offspring were prospectively assessed using semi-structured clinical interviews annually and completed the Hypomania Checklist-32 Revised (HCL-32). Clinically significant sub-threshold hypomanic symptoms (CSHS) were coded.
HCL-32 total and active or elated scores were higher in control compared with high-risk offspring, whereas 14% of high-risk and 0% of control offspring had CSHS. High-risk offspring with CSHS had a fivefold increased risk of developing recurrent major depression (P=0.0002). The median onset of CSHS in high-risk offspring was 16.4 (6-31) years and was before the onset of major mood episodes.
CSHS are precursors to major mood episodes in high-risk offspring and could identify individuals at ultra-high risk for developing bipolar disorder.
None.
© The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

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Open Access
Yes
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11/04/2017 19:15
Last modification date
20/08/2019 14:19
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