Long-term effects of in utero exposure to cyclosporin A on renal function in the rabbit.

Details

Serval ID
serval:BIB_33237
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term effects of in utero exposure to cyclosporin A on renal function in the rabbit.
Journal
Journal of the American Society of Nephrology
Author(s)
Tendron-Franzin A., Gouyon J.B., Guignard J.P., Decramer S., Justrabo E., Gilbert T., Semama D.S.
ISSN
1046-6673 (Print)
ISSN-L
1046-6673
Publication state
Published
Issued date
2004
Volume
15
Number
10
Pages
2687-2693
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
The number of pregnant women who receive cyclosporin A (CsA) after transplantation or for autoimmune disease has increased. CsA and its metabolites can cross the placental barrier and thus interfere with fetal development. It was shown previously that rabbits that were exposed in utero to 10 mg/kg per d CsA from the 14th to the 18th day of gestation presented a 25% nephron reduction. Thus, this study was conducted to assess the long-term systemic and renal effects of a CsA-induced nephron reduction. Twenty-two pregnant New Zealand white rabbits were randomly divided into two groups: Twelve received 10 mg/kg per d CsA from day 14 to day 18 of gestation, and 10 were used as controls. Rabbits that were born to these animals were evaluated at 4, 11, 18, and 35 wk of life. Pups that were exposed antenatally to CsA presented first a permanent nephron deficit; second, glomerular, tubular, and intrarenal hemodynamics dysfunction; third, enlarged kidneys with numerous tubular and glomerular lesions; and, fourth, an endothelin-dependent systemic hypertension that worsened with age. In utero exposure to CsA induced a nephron reduction that led to systemic hypertension and progressive chronic renal insufficiency in adulthood. A long-term clinical survey is mandatory in infants who are born to mothers who were treated with cyclosporin during pregnancy.
Keywords
Abnormalities, Drug-Induced/diagnosis, Abnormalities, Drug-Induced/etiology, Animals, Animals, Newborn, Cyclosporine/toxicity, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Glomerular Filtration Rate/drug effects, Hypertension/physiopathology, Immunosuppressive Agents/toxicity, Kidney/drug effects, Kidney/embryology, Pregnancy, Pregnancy, Animal, Prenatal Exposure Delayed Effects, Rabbits, Random Allocation, Renal Circulation/drug effects, Risk Factors, Sensitivity and Specificity, Teratology, Vascular Resistance/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:32
Last modification date
20/08/2019 13:18
Usage data