Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients.

Details

Serval ID
serval:BIB_331FD685E45F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients.
Journal
Haematologica
Author(s)
Ramos-Campoy S., Puiggros A., Beà S., Bougeon S., Larráyoz M.J., Costa D., Parker H., Rigolin G.M., Ortega M., Blanco M.L., Collado R., Salgado R., Baumann T., Gimeno E., Moreno C., Bosch F., Calvo X., Calasanz M.J., Cuneo A., Strefford J.C., Nguyen-Khac F., Oscier D., Haferlach C., Schoumans J., Espinet B.
ISSN
1592-8721 (Electronic)
ISSN-L
0390-6078
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK, 46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity [0-2, 3-4 and ≥5 abnormalities] was also analyzed. No significant differences in the percentage of patients classified into each category were detected, but only a moderate agreement was observed between methods when focusing in individual cases (κ=0.507; p.
Pubmed
Open Access
Yes
Create date
29/03/2021 12:54
Last modification date
30/12/2021 6:35
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