Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy.

Details

Serval ID
serval:BIB_331A77606E02
Type
Article: article from journal or magazin.
Collection
Publications
Title
Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy.
Journal
Metabolism: Clinical and Experimental
Author(s)
Seaquist E.R., Tkac I., Damberg G., Thomas W., Gruetter R.
ISSN
0026-0495 (Print)
ISSN-L
0026-0495
Publication state
Published
Issued date
2005
Volume
54
Number
8
Pages
1008-1013
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Abstract
Hyperglycemia and diabetes alter the function and metabolism of many tissues. The effect on the brain remains poorly defined, but some animal data suggest that chronic hyperglycemia reduces rates of brain glucose transport and/or metabolism. To address this question in human beings, we measured glucose in the occipital cortex of patients with poorly controlled diabetes and healthy volunteers at the same levels of plasma glucose using proton magnetic resonance spectroscopy. Fourteen patients with poorly controlled diabetes (hemoglobin A 1c = 9.8% +/- 1.7%, mean +/- SD) and 14 healthy volunteers similar with respect to age, sex, and body mass index were studied at a plasma glucose of 300 mg/dL. Brain glucose concentrations of patients with poorly controlled diabetes were lower but not statistically different from those of control subjects (4.7 +/- 0.9 vs 5.3 +/- 1.1 micromol/g wet wt; P = .1). Our sample size gave 80% power to detect a difference as small as 1.1 micromol/g wet wt. We conclude that chronic hyperglycemia in diabetes does not alter brain glucose concentrations in human subjects.
Keywords
Adult, Brain/metabolism, Diabetes Mellitus, Type 1/diagnosis, Diabetes Mellitus, Type 1/metabolism, Diabetes Mellitus, Type 2/diagnosis, Diabetes Mellitus, Type 2/metabolism, Female, Glucose/pharmacokinetics, Glucose Clamp Technique, Hemoglobin A, Glycosylated/metabolism, Humans, Insulin/blood, Magnetic Resonance Spectroscopy/methods, Male, Middle Aged, Protons
Pubmed
Web of science
Create date
04/08/2010 15:28
Last modification date
20/08/2019 13:18
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