Omics meets hypothesis-driven research. Partnership for innovative discoveries in vascular biology and angiogenesis.

Details

Serval ID
serval:BIB_331975AD5496
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Omics meets hypothesis-driven research. Partnership for innovative discoveries in vascular biology and angiogenesis.
Journal
Thrombosis and Haemostasis
Author(s)
Rüegg C., Tissot J.D., Farmer P., Mariotti A.
ISSN
0340-6245
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
100
Number
5
Pages
738-746
Language
english
Abstract
The emergence of omics technologies allowing the global analysis of a given biological or molecular system, rather than the study of its individual components, has revolutionized biomedical research, including cardiovascular medicine research in the past decade. These developments raised the prospect that classical, hypothesis-driven, single gene-based approaches may soon become obsolete. The experience accumulated so far, however, indicates that omic technologies only represent tools similar to those classically used by scientists in the past and nowadays, to make hypothesis and build models, with the main difference that they generate large amounts of unbiased information. Thus, omics and classical hypothesis-driven research are rather complementary approaches with the potential to effectively synergize to boost research in many fields, including cardiovascular medicine. In this article we discuss some general aspects of omics approaches, and review contributions in three areas of vascular biology, thrombosis and haemostasis, atherosclerosis and angiogenesis, in which omics approaches have already been applied (vasculomics).
Keywords
Animals, Atherosclerosis, Biomedical Research, Cardiovascular Diseases, Gene Expression Regulation, Genetic Predisposition to Disease, Genomics, Hemostasis, Humans, Models, Animal, Neovascularization, Physiologic, Reproducibility of Results, Systems Biology, Thrombosis
Pubmed
Web of science
Create date
29/01/2009 22:13
Last modification date
20/08/2019 13:18
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