Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.

Details

Serval ID
serval:BIB_32C97A6075C9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.
Journal
Assay and Drug Development Technologies
Author(s)
Cotecchia S., Fanelli F., Costa T.
ISSN
1540-658X (Print)
ISSN-L
1540-658X
Publication state
Published
Issued date
2003
Volume
1
Number
2
Pages
311-316
Language
english
Abstract
Mutations of GPCRs can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis; others occur spontaneously in human diseases. The analysis of constitutively active GPCR mutants has attracted a large interest in the past decade, providing an important contribution to our understanding of the molecular mechanisms underlying receptor function and drug action.
Keywords
Drug Therapy/trends, Forecasting, Mutagenesis, Site-Directed, Mutation, Receptors, G-Protein-Coupled/drug effects, Receptors, G-Protein-Coupled/genetics
Pubmed
Web of science
Create date
24/01/2008 11:05
Last modification date
20/08/2019 13:18
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