Relationship between expression of Fc gamma receptors or Ia antigens and cytolytic activities of alloactivated human T cells

Details

Serval ID
serval:BIB_32B20CFABD23
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relationship between expression of Fc gamma receptors or Ia antigens and cytolytic activities of alloactivated human T cells
Journal
Clinical Immunology and Immunopathology
Author(s)
Moretta  A., Mingari  M. C., Cerottini  J. C., Fauci  A. S., Moretta  L.
ISSN
0090-1229 (Print)
Publication state
Published
Issued date
02/1983
Volume
26
Number
2
Pages
232-9
Notes
Journal Article --- Old month value: Feb
Abstract
The relationship between expression of Ia antigens or Fc gamma receptors (Fc gamma R) and different cytolytic activities of mixed leukocyte culture (MLC)-activated T-cell populations was studied. Lymphocytes mediating specific lysis of target cells bearing the stimulating alloantigens (CTL) could clearly be distinguished from cells mediating antibody-dependent cellular cytotoxicity (ADCC) in that CTL were Fc gamma R- while cells mediating ADCC were Fc gamma R+. In contrast, MLC-generated natural killer (NK) cells were distributed in both the Fc gamma R- and Fc gamma R+ cell fractions. The presence or absence of Ia antigens did not correlate with any of the cytolytic activities studied. In addition, Fc gamma R- and not Fc gamma R+ cells responded in the secondary MLC. Thus, although Fc gamma R+ cells are generated in large numbers in MLC, they do not appear to play a direct role in specific cytotoxicity nor do they proliferate in response to secondary stimulation. However, their ability, following MLC generation, to mediate NK activity and ADCC, both of which may contribute to in vitro and in vivo lysis of allogeneic cells, might explain their appearance following allogenic stimulation.
Keywords
Antibody-Dependent Cell Cytotoxicity Cytotoxicity, Immunologic HLA Antigens/*analysis Humans Lymphocyte Culture Test, Mixed Receptors, Fc/*analysis Receptors, IgG T-Lymphocytes/*immunology
Pubmed
Web of science
Create date
28/01/2008 11:14
Last modification date
20/08/2019 13:18
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