Regulation of inflammasome activity.

Details

Serval ID
serval:BIB_32B032595736
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regulation of inflammasome activity.
Journal
Immunology
Author(s)
Guarda G., So A.
ISSN
1365-2567[electronic], 0019-2805[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
130
Number
3
Pages
329-336
Language
english
Notes
BIB_750BD54D9877
Abstract
Summary Interleukin-1beta (IL-1beta) is a potent inflammatory cytokine, which is implicated in acute and chronic inflammatory disorders. The activity of IL-1beta is regulated by the proteolytic cleavage of its inactive precursor resulting in the mature, bioactive form of the cytokine. Cleavage of the IL-1beta precursor is performed by the cysteine protease caspase-1, which is activated within protein complexes termed 'inflammasomes'. To date, four distinct inflammasomes have been described, based on different core receptors capable of initiating complex formation. Both the host and invading pathogens need to control IL-1beta production and this can be achieved by regulating inflammasome activity. However, we have, as yet, little understanding of the mechanisms of this regulation. In particular the negative feedbacks, which are critical for the host to limit collateral damage of the inflammatory response, remain largely unexplored. Recent exciting findings in this field have given us an insight into the potential of this research area in terms of opening up new therapeutic avenues for inflammatory disorders.
Keywords
Inflammasomes, Interleukin-1 Beta, Regulators, Interleukin-1-Beta Converting-Enzyme, Familial Mediterranean Fever, Proteinase-Inhibitor 9, Gamma-Inducing Factor, Muckle-Wells-Syndrome, NF-Kappa-B, Caspase-1 Activation, NLRP3 Inflammasome, NALP3 Inflammasome, Autoinflammatory Disorder
Pubmed
Web of science
Open Access
Yes
Create date
15/06/2011 10:40
Last modification date
20/08/2019 13:18
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