Performance characteristics of centrifugal pumps with heparin surface coating

Details

Serval ID
serval:BIB_32AE3769E713
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Performance characteristics of centrifugal pumps with heparin surface coating
Journal
Thoracic and Cardiovascular Surgeon
Author(s)
von Segesser  L. K., Lachat  M., Gallino  A., Weiss  B. M., Leskosek  B., Garcia  E., Hanseler  E., von Felten  A., Turina  M.
ISSN
0171-6425
Publication state
Published
Issued date
08/1990
Peer-reviewed
Oui
Volume
38
Number
4
Pages
224-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Heparin surface coating is one approach to improve the biocompatibility of existing blood pumps used for mechanical circulatory support. Experimental evaluation of centrifugal pumps with heparin surface coating was performed during open chest left heart bypass (3.7 L/min over 6 hours) in two series of bovine experiments. Eight calves (74 +/- 4 kg) were perfused either by heparin surface coated equipment without systemic heparinization or uncoated equipment with systemic heparinization (300 I. U,/kg bodyweight; ACT greater than 400 s). A standard battery of analyses was performed before and at regular intervals after onset of perfusion. At the end of perfusion all pump-heads were gently rinsed. There were no macroscopic clots for both groups whereas macroscopic clots were observed in uncoated tubings introduced for control in the group perfused without systemic heparinization. The hemodynamics were significantly better in the group perfused without systemic heparinization and maintained functional coagulation system. Clinical application of heparin surface coated equipment during resection of thoraco-abdominal aortic aneurysms is showing promising results in 12 patients.
Keywords
Animals *Biocompatible Materials Cardiopulmonary Bypass Cattle *Heart-Assist Devices *Heparin Time Factors
Pubmed
Web of science
Create date
14/02/2008 14:19
Last modification date
20/08/2019 13:18
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