Recent advances in primary cutaneous T-cell lymphoma.

Details

Serval ID
serval:BIB_32A19CB07408
Type
Article: article from journal or magazin.
Collection
Publications
Title
Recent advances in primary cutaneous T-cell lymphoma.
Journal
Current opinion in oncology
Author(s)
DeSimone J.A., Sodha P., Ignatova D., Dummer R., Cozzio A., Guenova E.
ISSN
1531-703X (Electronic)
ISSN-L
1040-8746
Publication state
Published
Issued date
03/2015
Peer-reviewed
Oui
Volume
27
Number
2
Pages
128-133
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of skin-homing T-cell neoplasms, which represent approximately 75% of all primary cutaneous lymphomas. Currently available drug therapies, when effective, simply control disease and the only option for curing CTCL is stem cell transplant.
In the last year, there has been an incredible effort made to improve the understanding and treatment of CTCL. Recent findings indicate that epigenetic aberrations are integral to active disease. Furthermore, multiple tumor-derived immunological factors have also been shown to inhibit viability, proliferation, and cytokine production of nonmalignant T cells. Several novel targeted therapies show great potential, most promising being antibody drug conjugates targeting surface markers such as CD30 in some CTCL subtypes. Additional attractive targets involve the global modulation of epigenetic markers such as demethylation agents or HDAC inhibitors, either as single agents or in combination therapies.
This is a concise review of recent advances in the field of CTCL with special focus on research articles over the preceding year.
Keywords
Antineoplastic Agents, Alkylating/administration & dosage, Combined Modality Therapy, Humans, Immunologic Factors/administration & dosage, Lymphoma, T-Cell, Cutaneous/drug therapy, Lymphoma, T-Cell, Cutaneous/pathology, Phototherapy/methods, Phototherapy/trends, Skin Neoplasms/drug therapy, Skin Neoplasms/pathology, Stem Cell Transplantation/methods, Stem Cell Transplantation/trends
Pubmed
Web of science
Create date
27/08/2020 13:59
Last modification date
02/09/2020 5:26
Usage data