Photorefractive keratectomy using solid state laser 213 nm and excimer laser 193 nm: a randomized, contralateral, comparative, experimental study.

Details

Serval ID
serval:BIB_329DB23209DF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Photorefractive keratectomy using solid state laser 213 nm and excimer laser 193 nm: a randomized, contralateral, comparative, experimental study.
Journal
Investigative ophthalmology & visual science
Author(s)
Tsiklis N.S., Kymionis G.D., Kounis G.A., Naoumidi I.I., Pallikaris I.G.
ISSN
0146-0404 (Print)
ISSN-L
0146-0404
Publication state
Published
Issued date
04/2008
Peer-reviewed
Oui
Volume
49
Number
4
Pages
1415-1420
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
To compare histopathologic changes after photorefractive keratectomy (PRK) for myopia using either a solid state laser (SSL) at 213 nm or an excimer laser (EL) at 193 nm in an experimental model.
Forty pigmented rabbits (80 eyes) underwent myopic PRK for the correction of 6 D. Photoablation was randomly assigned, with a solid state laser used in one eye and an EL in the fellow eye. Rabbits were killed immediately after ablation (n = 10) or at 7 days (n = 10), 1 month (n = 8), 3 months (n = 6), or 12 months (n = 6) after surgery. Corneal tissue was preserved for light microscopy and transmission electron microscopy at all postoperative intervals.
All eyes reepithelialized in 1 week with no early or late postoperative complication. Immediately after ablation, light, scanning, and transmission electron microscopy revealed relatively smooth ablation surfaces in both groups. Seven days after surgery, epithelium in the SSL specimens appeared thinner than in the EL specimens. Activated keratocytes were observed adjacent to the epithelium in both groups, whereas endothelial cells demonstrated normal morphology. At 1, 3, and 12 months after surgery, tissue appearance of all corneal layers was similar in both groups.
PRK in rabbits using ultraviolet SSL and EL revealed similar histopathologic findings up to 1 year after surgery.
Keywords
Animals, Cornea/surgery, Cornea/ultrastructure, Corneal Stroma/ultrastructure, Disease Models, Animal, Epithelium, Corneal/ultrastructure, Female, Lasers, Excimer, Lasers, Solid-State, Male, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Myopia/pathology, Myopia/surgery, Photorefractive Keratectomy/methods, Rabbits, Random Allocation
Pubmed
Web of science
Open Access
Yes
Create date
02/10/2019 8:52
Last modification date
06/10/2019 5:26
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