Cyclosporin A modulation of early virologic and immunologic events during primary simian immunodeficiency virus infection in rhesus monkeys

Details

Serval ID
serval:BIB_32823A4329E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cyclosporin A modulation of early virologic and immunologic events during primary simian immunodeficiency virus infection in rhesus monkeys
Journal
Journal of Infectious Diseases
Author(s)
Martin  L. N., Murphey-Corb  M., Mack  P., Baskin  G. B., Pantaleo  G., Vaccarezza  M., Fox  C. H., Fauci  A. S.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
08/1997
Volume
176
Number
2
Pages
374-83
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
Virologic and immunologic effects of immunomodulation during primary simian immunodeficiency virus (SIV) infection were examined in monkeys treated with cyclosporin or vehicle for 32 days beginning 5 days before SIV inoculation. Duration of antigenemia decreased in 5 of 7 treated monkeys, 2 having delayed onset and peak of antigenemia. Although proviral DNA levels in blood and lymph nodes and infected cell numbers in lymph nodes were transiently decreased, levels were similar to those in controls by day 14. The CD4:CD8 ratio and percentage of CD4+ CD29+ cells decreased in controls 14 days after inoculation, but this decrease was delayed in treated monkeys. Two treated monkeys demonstrated rapid disease, with progressive antigenemia preceding early deaths 90-96 days after inoculation. Nevertheless, immunomodulation influenced the kinetics of primary SIV infection in some monkeys, supporting the rationale of careful exploration of the strategy of interference with the heightened state of cellular activation together with direct antiretroviral therapy in human immunodeficiency virus infection.
Keywords
Animals Antibodies, Viral/blood Antigens, CD29/analysis Antigens, Viral/blood CD4-CD8 Ratio Cyclosporine/blood/*pharmacology DNA, Viral/blood HIV-1/drug effects/physiology Humans Immunosuppressive Agents/blood/*pharmacology Lymph Nodes/virology Lymphocyte Subsets Macaca mulatta Male Simian Acquired Immunodeficiency Syndrome/*immunology/virology Simian immunodeficiency virus/drug effects/immunology/physiology Virus Replication/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:14
Last modification date
20/08/2019 13:18
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