The kidney during hibernation and arousal from hibernation. A natural model of organ preservation during cold ischaemia and reperfusion.

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Serval ID
serval:BIB_326EDB369D07
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The kidney during hibernation and arousal from hibernation. A natural model of organ preservation during cold ischaemia and reperfusion.
Journal
Nephrology, Dialysis, Transplantation
Author(s)
Zancanaro C., Malatesta M., Mannello F., Vogel P., Fakan S.
ISSN
0931-0509 (Print)
ISSN-L
0931-0509
Publication state
Published
Issued date
1999
Volume
14
Number
8
Pages
1982-1990
Language
english
Abstract
BACKGROUND: During hibernation the kidney is in a hypothermic condition where renal blood flow is minimal and urine production is much reduced. Periodical arousal from hibernation is associated with kidney reperfusion at increasing body temperature, and restored urine production rate.
METHODS: To assess the degree of structural preservation during such extreme conditions, the kidney cortex was investigated by means of electron microscopy in the dormouse Muscardinus avellanarius during winter hibernation, arousal from hibernation and the summer active period.
RESULTS: Results show that the fine structure of the kidney cortex is well preserved during hibernation. In the renal corpuscle, a sign of slight lesion was the focal presence of oedematous endothelial cells and/or podocytes. Proximal convoluted tubule cells showed fully preserved ultrastructure and polarity, and hypertrophic apical endocytic apparatus. Structural changes were associated with increased plasma electrolytes, creatinine and urea nitrogen, and proteinuria. During the process of arousal the fine structure of the kidney cortex was also well maintained.
CONCLUSION: These results demonstrate that dormice are able to fully preserve kidney cortex structure under extreme conditions resembling e.g. severe ischaemia or hypothermic organ storage for transplantation, and reperfusion. Elucidation of the mechanisms involved in such a natural model of organ preservation could be relevant to human medicine.
Keywords
Animals, Arousal/physiology, Blood/metabolism, Cryopreservation, Hibernation/physiology, Kidney/physiology, Kidney/ultrastructure, Kidney Tubules/ultrastructure, Microscopy, Electron, Organ Preservation, Renal Circulation, Reperfusion, Rodentia, Urine/chemistry
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 17:33
Last modification date
25/09/2019 6:08
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