Smoking offsets the metabolic benefits of parental longevity in women: the CoLaus study.

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State: Public
Version: author
Serval ID
serval:BIB_326DA088D7E2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Smoking offsets the metabolic benefits of parental longevity in women: the CoLaus study.
Journal
Preventive Medicine
Author(s)
Jaunin J., Bochud M., Marques-Vidal P., Vollenweider P., Waeber G., Mooser V., Paccaud F.
ISSN
1096-0260[electronic]
ISSN-L
0091-7435
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
48
Number
3
Pages
224-231
Language
english
Abstract
OBJECTIVE: We evaluated whether subjects with long-lived parents show lower levels of cardiovascular risk factors, including the metabolic syndrome. METHODS: We analyzed data from a Swiss population-based sample (1163 men and 1398 women) aged 55-75 years from Lausanne. Participants were stratified by number of parents (0, 1, 2) who survived to 85 years or more. The associations of parental longevity with cardiovascular risk factors and related metabolic variables were analyzed using multiple linear regressions. RESULTS: Age-adjusted metabolic syndrome prevalence varied from 24.8%, 20.5% to 13.8% in women (P<0.05) and from 28.8%, 32.1% to 27.6% in men (not significant) with 0, 1 and 2 long-lived parents. The association between parental longevity and metabolic syndrome prevalence was particularly strong in women who had never smoked. In this group, women with 2 long-lived parents had lower Body Mass Index and smaller waist circumference. In never-smokers of both genders, mean (95% CI) adjusted High Density Lipoprotein-cholesterol levels were 1.64(1.61-1.67), 1.67(1.65-1.70) and 1.71(1.65-1.76) mmol/L for 0, 1 and 2 long-lived parents (P<0.01), respectively. The trend was not significant in former and current smokers. CONCLUSIONS: In women, not in men, parental longevity is associated with a better metabolic profile. The metabolic benefits of having long-lived parents are offset by smoking.
Keywords
Aged, Biological Markers/blood, Body Mass Index, Cardiovascular Diseases/blood, Cardiovascular Diseases/epidemiology, Female, Humans, Linear Models, Longevity/genetics, Colaus Study
Pubmed
Web of science
Open Access
Yes
Create date
02/03/2009 18:52
Last modification date
20/08/2019 13:18
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