Experimental evaluation of the Dideco D903 Avant 1.7 hollow-fibre membrane oxygenator

Details

Serval ID
serval:BIB_325C739D86E6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Experimental evaluation of the Dideco D903 Avant 1.7 hollow-fibre membrane oxygenator
Journal
Perfusion
Author(s)
Mueller  X. M., Tevaearai  H. T., Augstburger  M., Horisberger  J., von Segesser  L. K.
ISSN
0267-6591
Publication state
Published
Issued date
09/1998
Peer-reviewed
Oui
Volume
13
Number
5
Pages
353-9
Notes
Journal Article --- Old month value: Sep
Abstract
Membrane oxygenators have now gained wide acceptance. A new hollow-fibre membrane oxygenator, the Dideco D903 Avant 1.7, with an optimized membrane surface (1.7 m2) and a wavy blood flow pattern, was tested for gas transfer and blood path resistance in a standardized setting with surviving animals. Three calves (mean body weight 63.29 +/- 2.9 kg) were connected to cardiopulmonary bypass by jugular venous and carotid arterial cannulation, classic roller pump and the Dideco D903 oxygenator with a mean flow rate of 53 +/- 0.1 ml/kg/min for 6 h. After this time, the animals were weaned from the CPB and thereafter from the ventilator. After 7 days, the animals were killed electively. Blood gas analysis was performed before bypass, after mixing (10 min) and then hourly for the 6 h of perfusion. Further samples were taken 30 min (spontaneous breathing) and 60 min after bypass (extubated). Physiological blood gas values could be maintained throughout perfusion in all animals. Mean arterial oxygen saturation varied between 99.3% and 99.7% for the arterial side of the oxygenator compared to 64.6% and 71% for the venous side. The highest mean pressure drop through the oxygenator was 54 mmHg. Postbypass blood gas analysis showed physiological values and no evidence of major lung trauma or pulmonary oedema in relation to the 6 h perfusion. The hollow-fibre membrane oxygenator, Dideco D903, offers excellent gas exchange capabilities and a low pressure drop under experimental conditions, despite reduced membrane surface area. The post mortem examination did not show any deleterious lesion.
Keywords
Animals *Cardiac Surgical Procedures Cardiopulmonary Bypass/*methods Cattle Extracorporeal Membrane Oxygenation/*instrumentation *Oxygenators, Membrane
Pubmed
Web of science
Create date
14/02/2008 14:18
Last modification date
20/08/2019 13:17
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