Toward the effective surveillance of hypospadias.

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Serval ID
serval:BIB_32493
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Toward the effective surveillance of hypospadias.
Journal
Environmental Health Perspectives
Author(s)
Dolk H., Vrijheid M., Scott J.E., Addor M.C., Botting B., de Vigan C., de Walle H., Garne E., Loane M., Pierini A., Garcia-Minaur S., Physick N., Tenconi R., Wiesel A., Calzolari E., Stone D.
ISSN
0091-6765
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
112
Number
3
Pages
398-402
Language
english
Abstract
Concern about apparent increases in the prevalence of hypospadias--a congenital male reproductive-tract abnormality--in the 1960s to 1980s and the possible connection to increasing exposures to endocrine-disrupting chemicals have underlined the importance of effective surveillance of hypospadias prevalence in the population. We report here the prevalence of hypospadias from 1980 to 1999 in 20 regions of Europe with EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers, 14 of which implemented a guideline to exclude glanular hypospadias. We also report data from the England and Wales National Congenital Anomaly System (NCAS). Our results do not suggest a continuation of rising trends of hypospadias prevalence in Europe. However, a survey of the registers and a special validation study conducted for the years 1994-1996 in nine EUROCAT registers as well as NCAS identified a clear need for a change in the guidelines for registration of hypospadias. We recommend that all hypospadias be included in surveillance, but that information from surgeons be obtained to verify location of the meatus, and whether surgery was performed, in order to interpret trends. Investing resources in repeated special surveys may be more cost-effective than continuous population surveillance. We conclude that it is doubtful whether we have had the systems in place worldwide for the effective surveillance of hypospadias in relation to exposure to potential endocrine-disrupting chemicals.
Keywords
Confounding Factors (Epidemiology), Endocrine System, Environmental Pollutants, Epidemiologic Studies, Europe, Guidelines as Topic, Humans, Hypospadias, Infant, Newborn, Male, Population Surveillance, Prevalence, Registries, Reproducibility of Results
Pubmed
Web of science
Create date
19/11/2007 12:31
Last modification date
20/08/2019 13:17
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