Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues

Details

Serval ID
serval:BIB_323D903163BA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues
Journal
Journal of Lipid Research
Author(s)
Minehira-Castelli K., Leonard  S. W., Walker  Q. M., Traber  M. G., Young  S. G.
ISSN
0022-2275
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
47
Number
8
Pages
1733-8
Language
english
Abstract
alpha-Tocopherol is a lipid-soluble antioxidant that helps to prevent oxidative damage to cellular lipids. alpha-Tocopherol is absorbed by the intestine and is taken up and retained by the liver; it is widely presumed that alpha-tocopherol is then delivered to peripheral tissues by the secretion of VLDL. To determine whether VLDL secretion is truly important for the delivery of alpha-tocopherol to peripheral tissues, we examined alpha-tocopherol metabolism in mice that lack microsomal triglyceride transfer protein (Mttp) expression in the liver and therefore cannot secrete VLDL (Mttp(Delta/Delta) mice). Mttp(Delta/Delta) mice have low plasma lipid levels and increased stores of lipids in the liver. Similarly, alpha-tocopherol levels in the plasma were lower in Mttp(Delta/Delta) mice than in controls, whereas hepatic alpha-tocopherol stores were higher. However, alpha-tocopherol levels in the peripheral tissues of Mttp(Delta/Delta) mice were nearly identical to those of control mice, suggesting that VLDL secretion is not critical for the delivery of alpha-tocopherol to peripheral tissues. When fed a diet containing deuterated alpha-tocopherol, Mttp(Delta/Delta) and control mice had similar incorporation of deuterated alpha-tocopherol into plasma and various peripheral tissues. We conclude that the absence of VLDL secretion has little effect on the stores of alpha-tocopherol in peripheral tissues, at least in the mouse.
Keywords
AnimalsApolipoproteins B/metabolismBiological TransportCarrier Proteins/genetics/metabolismDeuteriumLipid Metabolism/physiologyLipids/bloodLipoproteins, VLDL/genetics/metabolism/*physiologyLiver/metabolismMiceMice, TransgenicVitamin E/metabolismalpha-Tocopherol/*metabolism
Pubmed
Web of science
Open Access
Yes
Create date
20/02/2009 12:43
Last modification date
20/08/2019 13:17
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