Irreversibility of cyclosporine-induced renal function impairment in heart transplant recipients
Details
Serval ID
serval:BIB_322F9D071214
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Irreversibility of cyclosporine-induced renal function impairment in heart transplant recipients
Journal
Journal of Heart and Lung Transplantation
ISSN
1053-2498
Publication state
Published
Issued date
10/1993
Peer-reviewed
Oui
Volume
12
Number
5
Pages
846-50
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Abstract
The use of cyclosporine therapy for heart transplant recipients has been associated with a significant improvement of graft survival. Renal function impairment is a frequent finding in patients chronically treated with cyclosporine. The purpose of this prospective randomized study was to establish renal function in a group of heart transplant recipients receiving chronic cyclosporine treatment and to test the hypothesis of reversibility of cyclosporine-induced nephropathy by late reduction of cyclosporine. A total of 28 patients who underwent operation at least 18 months before this study began were randomly assigned to either group A (n = 14), in which the whole-blood polyclonal cyclosporine target trough level was reduced from 400 to 600 micrograms/L to 200 to 400 micrograms/L, and group B (n = 14), in which the level was maintained at 400 to 600 micrograms/L. Renal and cardiac function were assessed by paraaminohippuric acid, inulin and lithium clearances and heart catheterization, respectively, at entry and 4 months later. Cellular rejection in the transplanted heart was monitored by at least four endomyocardial biopsies every 14 days with the histologic Texas scale (grading: 0 to 10). In heart recipients renal blood flow (592 +/- 202 ml/min/1.73 m2) and glomerular-filtration rate (74 +/- 33 ml/min/1.73 m2) were significantly lower (p < 0.01), and mean arterial blood pressure (109 +/- 13 mm Hg) and renal vascular resistance (22.4 +/- 9 mm Hg/dl/min/1.73 m2) were significantly higher than the corresponding values in normal controls (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult
Blood Pressure/drug effects
Cyclosporine/administration & dosage/*adverse effects/blood
Glomerular Filtration Rate/drug effects
Graft Rejection/*prevention & control
Graft Survival/drug effects
*Heart Transplantation/physiology
Humans
Kidney/blood supply/*drug effects/physiopathology
Prospective Studies
Renal Circulation/drug effects
Urine
Vascular Resistance/drug effects
Pubmed
Web of science
Create date
14/02/2008 15:16
Last modification date
20/08/2019 14:17