Pulmonary disposition of vancomycin in critically ill patients.

Details

Serval ID
serval:BIB_322A2DF7686C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Pulmonary disposition of vancomycin in critically ill patients.
Journal
European journal of clinical microbiology & infectious diseases
Author(s)
Georges H., Leroy O., Alfandari S., Guery B., Roussel-Delvallez M., Dhennain C., Beaucaire G.
ISSN
0934-9723 (Print)
ISSN-L
0934-9723
Publication state
Published
Issued date
05/1997
Peer-reviewed
Oui
Volume
16
Number
5
Pages
385-388
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Abstract
Vancomycin penetration in epithelium lining fluid was studied in ten mechanically ventilated patients with methicillin-resistant Staphylococcus aureus pneumonia 24 hours after the onset of treatment. Vancomycin was given intravenously at a daily dose of 30 mg/kg. Vancomycin levels were detectable in four patients (range, 1-2.77 micrograms/ml). Concordance between high plasma concentrations (> 20 micrograms/ml) and detectable vancomycin levels in epithelium lining fluid was noted. These results suggest that the pulmonary disposition of vancomycin remains low for most patients 24 h after the onset of treatment compared with the minimum inhibitory concentrations for most gram-positive organisms. One therapeutic goal of vancomycin treatment could be to obtain through plasma levels of 20 micrograms/ml. Further studies are required to determine the clinical relevance of these observations.
Keywords
Aged, Anti-Bacterial Agents/pharmacokinetics, Anti-Bacterial Agents/therapeutic use, Bronchoalveolar Lavage Fluid/chemistry, Bronchoscopy, Critical Illness, Female, Humans, Injections, Intravenous, Male, Methicillin Resistance, Middle Aged, Pneumonia, Bacterial/diagnosis, Pneumonia, Bacterial/drug therapy, Pneumonia, Bacterial/physiopathology, Prospective Studies, Respiration, Artificial, Staphylococcal Infections/diagnosis, Staphylococcal Infections/drug therapy, Staphylococcal Infections/physiopathology, Treatment Outcome, Vancomycin/pharmacokinetics, Vancomycin/therapeutic use
Pubmed
Web of science
Create date
29/04/2021 10:59
Last modification date
17/07/2023 15:11
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