Endogenous estrogens increase postischemic hyperemia in the skin microcirculation
Details
Serval ID
serval:BIB_321A04FF583C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Endogenous estrogens increase postischemic hyperemia in the skin microcirculation
Journal
Journal of Cardiovascular Pharmacology
ISSN
0160-2446 (Print)
Publication state
Published
Issued date
05/2005
Volume
45
Number
5
Pages
414-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Estrogens have been recognized as a major regulator of vascular tone and structure, particularly in the skin. The objective of this study was to investigate the effects of endogenous estrogens on the skin microcirculation. Skin blood flow was measured at the forearm at rest and during postischemic hyperemia using laser Doppler flowmetry in 32 healthy women (mean age 34.5 +/- 3.9 years) involved in an in-vitro fertilization program. Women were treated for 10 to 12 days with gonadotropin-releasing hormone agonist (total dose 40.3 +/- 3.3 mg) and human menopausal gonadotropin (1942 +/- 801 IE) or follicle-stimulating hormone (2544 +/- 1071 IE) according to individual estrogen levels. Plasma estrogen levels increased from 132 +/- 90 pmol/L (36 +/- 25 pg/mL) to 8471 +/- 4386 pmol/L (2308 +/- 1195 pg/mL) during treatment (P < 0.0001). Maximal hyperemic blood flow increased from 353 +/- 81% before treatment to 516 +/- 144% after hormonal stimulation (P < 0.0001), whereas basal skin flow was not altered. This study shows that endogenous estrogens enhance the postischemic hyperemic response of the skin microcirculation.
Keywords
Adult
Estradiol/blood
Estrogens/*pharmacology
Female
Follicle Stimulating Hormone/physiology
Gonadotropin-Releasing Hormone/agonists
Humans
Hyperemia/*physiopathology
Ischemia/*complications
Laser-Doppler Flowmetry
Microcirculation/*drug effects
Progesterone/blood
Radioimmunoassay
Regional Blood Flow
Skin/*blood supply
Pubmed
Web of science
Create date
17/01/2008 17:38
Last modification date
20/08/2019 14:17