Tc-99m mebrofenin hepatobiliary scintigraphy to assess future liver remnant function before major liver surgery.
Details
Download: 37638473.pdf (953.46 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_320D6A0EAFB8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tc-99m mebrofenin hepatobiliary scintigraphy to assess future liver remnant function before major liver surgery.
Journal
Journal of surgical oncology
ISSN
1096-9098 (Electronic)
ISSN-L
0022-4790
Publication state
Published
Issued date
12/2023
Peer-reviewed
Oui
Volume
128
Number
8
Pages
1312-1319
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Assessment of liver function is paramount before hepatectomy. This study aimed to assess future liver remnant function (FLR-F) using hepatobiliary scintigraphy (HBS) and to compare it to FLR volume (FLR-V) in the prediction of posthepatectomy liver failure (PHLF). The impact of volume and function gains were also assessed in patients undergoing portal vein embolization (PVE) or liver venous deprivation (LVD).
All consecutive patients undergoing major hepatectomy between 02/2018 and 09/2021 with preoperative HBS were included. FLR-V was expressed as percentage of total liver volume and analyzed using preoperative computed tomography. FLR-V and FLR-F gains after embolization were expressed in percentage. Receiver operating characteristic analysis was performed to compare both methods in predicting PHLF.
Thirty-six patients were included. PVE and LVD were performed in 4 (11%) and 28 patients (78%), respectively. Overall, PHLF occurred in eight patients (22%). FLR-F gain after embolization showed significant ability to predict PHLF (area under the curve [AUC] = 0.789), with cut-off value of 150% showing a sensitivity of 1.00, a specificity of 0.42, and a negative predictive value of 1.00.
Preoperative HBS shows a high sensitivity to predict PHLF when HBS is performed twice to measure the function gain after venous embolization.
All consecutive patients undergoing major hepatectomy between 02/2018 and 09/2021 with preoperative HBS were included. FLR-V was expressed as percentage of total liver volume and analyzed using preoperative computed tomography. FLR-V and FLR-F gains after embolization were expressed in percentage. Receiver operating characteristic analysis was performed to compare both methods in predicting PHLF.
Thirty-six patients were included. PVE and LVD were performed in 4 (11%) and 28 patients (78%), respectively. Overall, PHLF occurred in eight patients (22%). FLR-F gain after embolization showed significant ability to predict PHLF (area under the curve [AUC] = 0.789), with cut-off value of 150% showing a sensitivity of 1.00, a specificity of 0.42, and a negative predictive value of 1.00.
Preoperative HBS shows a high sensitivity to predict PHLF when HBS is performed twice to measure the function gain after venous embolization.
Keywords
Humans, Liver Function Tests, Liver/diagnostic imaging, Liver/surgery, Hepatectomy/adverse effects, Hepatectomy/methods, Liver Failure/diagnostic imaging, Liver Failure/etiology, Radionuclide Imaging, Liver Neoplasms/surgery, Embolization, Therapeutic, Portal Vein/diagnostic imaging, Retrospective Studies, hepatectomy, hepatobiliary scintigraphy, liver failure, liver function test
Pubmed
Web of science
Open Access
Yes
Create date
29/08/2023 9:32
Last modification date
30/09/2024 7:04