Morphological and functional polymorphism within clonal thyroid nodules.

Details

Serval ID
serval:BIB_31F99492B059
Type
Article: article from journal or magazin.
Collection
Publications
Title
Morphological and functional polymorphism within clonal thyroid nodules.
Journal
The Journal of clinical endocrinology and metabolism
Author(s)
Aeschimann S., Kopp P.A., Kimura E.T., Zbaeren J., Tobler A., Fey M.F., Studer H.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Publication state
Published
Issued date
09/1993
Peer-reviewed
Oui
Volume
77
Number
3
Pages
846-851
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Thirty-nine thyroid nodules, removed because of recent growth, were analyzed morphologically by serial histological sections for the classical histomorphological hallmarks of follicular cell replication and for immunohistochemically demonstrable overexpression of the growth-associated ras-gene product p21ras. Clonal analysis was performed using the highly informative probe M27 beta that detects polymorphisms on the locus DXS255 of the X-chromosome. Twenty-four nodules were of clonal and 15 nodules were of poly-clonal origin. Only 3 out of the 24 clonal nodules were histomorphologically uniform. In all others, the structural hallmarks of active growth and the P21ras growth-marker expression were remarkably heterogeneous throughout the tumors. There were no histomorphological characteristics distinguishing these clonal tumors from polyclonal nodules. Even if a clonal thyroid tumor may be originally homogeneous in respect to the parameters studied here, mechanisms must exist that create wide heterogeneity of growth and of morphogenetic potential among the individual follicular cells during further expansion of the nodule. Thus, clonal nodules are much more common in nodular goiters than hitherto assumed on grounds of the classical morphological criteria. The diagnosis of a true monoclonal nodule can no longer rely on morphological and functional criteria alone but requires molecular or cytogenetic analysis of clonality.
Keywords
Adult, Aged, Aged, 80 and over, Clone Cells/pathology, Female, Humans, Immunoenzyme Techniques, Middle Aged, Polymorphism, Genetic, Proto-Oncogene Proteins p21(ras)/metabolism, Thyroid Nodule/genetics, Thyroid Nodule/metabolism, Thyroid Nodule/pathology, X Chromosome
Pubmed
Web of science
Create date
30/12/2020 16:45
Last modification date
31/12/2020 7:26
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