Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury.

Details

Serval ID
serval:BIB_31D14207E066
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury.
Journal
Nature communications
Author(s)
Bonizzato M., Pidpruzhnykova G., DiGiovanna J., Shkorbatova P., Pavlova N., Micera S., Courtine G.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
01/08/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
3015
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practical features necessary to be deployed daily during gait rehabilitation. Rats received a severe spinal cord contusion that led to leg paralysis. We engineered a proportional brain-spine interface whereby cortical ensemble activity constantly determines the amplitude of spinal cord stimulation protocols promoting leg flexion during swing. After minimal calibration time and without prior training, this neural bypass enables paralyzed rats to walk overground and adjust foot clearance in order to climb a staircase. Compared to continuous spinal cord stimulation, brain-controlled stimulation accelerates and enhances the long-term recovery of locomotion. These results demonstrate the relevance of brain-controlled neuromodulation therapies to augment recovery from motor disorders, establishing important proofs-of-concept that warrant clinical studies.
Keywords
Animals, Brain/physiopathology, Electric Stimulation Therapy, Electromyography, Extremities/physiopathology, Female, Gait, Locomotion, Muscles/physiopathology, Nerve Net/physiopathology, Rats, Inbred Lew, Recovery of Function/physiology, Reproducibility of Results, Spinal Cord/physiopathology, Spinal Cord Injuries/physiopathology, Walking
Pubmed
Web of science
Open Access
Yes
Create date
07/08/2018 11:39
Last modification date
20/08/2019 14:17
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