Modulatory growth effects of 3T3 fibroblasts on cocultivated human melanoma cells.

Details

Serval ID
serval:BIB_31B4C8EC405D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Modulatory growth effects of 3T3 fibroblasts on cocultivated human melanoma cells.
Journal
Anticancer Research
Author(s)
Benathan M., Pararas C., Frenk E.
ISSN
0250-7005
Publication state
Published
Issued date
1991
Peer-reviewed
Oui
Volume
11
Number
1
Pages
203-207
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
Normal epidermal melanocytes are stimulated in vitro by fibroblast- and keratinocyte-derived growth factors. In this work, the paracrine responsiveness of human melanoma cells was investigated by cocultivation with growth-inhibited 3T3 fibroblasts. In short-term assays (3-4 days), melanoma cell growth was found to be improved if the cells were plated onto half-confluent 3T3 cell monolayers. In contrast, long-term cocultivation (greater than 7 days) resulted in significant growth inhibition of melanoma cells. These phenomena were not observed when melanoma cells were grown in 3T3 cell supernatants, which suggests a possible mediation by extracellular matrix components and/or by heterologous junctional communications.
Keywords
Animals, Cell Communication, Cell Division, Cell Line, Fibroblasts, Humans, Kinetics, Melanoma, Mice
Pubmed
Web of science
Create date
15/02/2008 14:47
Last modification date
20/08/2019 13:17
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