Blocking stress signaling pathways with cell permeable peptides

Details

Serval ID
serval:BIB_31A36E1480A5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Blocking stress signaling pathways with cell permeable peptides
Journal
Advances in Experimental Medicine and Biology
Author(s)
Bonny  C.
ISSN
0065-2598 (Print)
Publication state
Published
Issued date
2006
Volume
588
Pages
133-43
Notes
Journal Article
Review
Abstract
Cells are continuously adapting to changes in their environment by activating extracellular stimuli-dependent signal transduction cascades. These cascades, or signaling pathways, culminate both in changes in genes expression and in the functional regulation of pre-existing proteins. The Mitogen-Activated Protein Kinases (MAPKs) constitute a structurally related class of signaling proteins whose distinctive feature is their ability to directly phosphorylate, and thereby modulate, the activity of the transcription factors that are targets of the initial stimuli. The specificity of activation of MAPK signaling modules is determined, at least for an important part, by the specificity of the protein-protein contacts that are required for the propagation of the signal. We will discuss how we may interfere with MAPK signaling by using short cell-permeable peptides able to block, through a competitive mechanisms, relevant protein-protein contacts, and their effects on signaling and cell function.
Keywords
Animals Apoptosis Enzyme Activation Hela Cells Humans MAP Kinase Kinase 4/metabolism *MAP Kinase Signaling System Mice Models, Biological Peptides/chemistry Permeability Phosphorylation Protein Isoforms *Signal Transduction p38 Mitogen-Activated Protein Kinases/metabolism
Pubmed
Web of science
Create date
25/01/2008 14:16
Last modification date
20/08/2019 13:17
Usage data