The effect of botulinum toxin type a on overactive bladder symptoms in patients with multiple sclerosis: a pilot study.

Details

Serval ID
serval:BIB_318C10B2D988
Type
Article: article from journal or magazin.
Collection
Publications
Title
The effect of botulinum toxin type a on overactive bladder symptoms in patients with multiple sclerosis: a pilot study.
Journal
Journal of Urology
Author(s)
Mehnert U., Birzele J., Reuter K., Schurch B.
ISSN
1527-3792 (Electronic)
ISSN-L
0022-5347
Publication state
Published
Issued date
2010
Volume
184
Number
3
Pages
1011-1016
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
PURPOSE: Patients with multiple sclerosis often experience overactive bladder symptoms. High dose intradetrusor botulinum toxin A treatment is effective but often results in urinary retention and urinary diversion via a catheter. In this pilot study we evaluated whether only 100 U botulinum toxin A would significantly decrease overactive bladder symptoms in patients with multiple sclerosis without impairing pretreatment voluntary voiding.
MATERIALS AND METHODS: Included in our study were 12 patients with multiple sclerosis who had overactive bladder symptoms such as urgency, frequency and/or urgency incontinence. The treatment effect was evaluated using data on 3 consecutive visits, that is before, and a mean +/- SD of 46.2 +/- 11.9 and 101 +/- 21 days after intradetrusor injection of 100 U Botox, including the results of cystometry and uroflowmetry at visits 1 and 2, and uroflowmetry alone at visit 3. Patients completed a 3-day voiding diary for all 3 visits.
RESULTS: Maximum bladder capacity significantly increased and maximum detrusor pressure decreased. Daytime and nighttime frequency, urgency and pad use significantly decreased. Post-void residual volume significantly increased initially but decreased until 12 weeks. Median time to re-injection due to recurrent overactive bladder symptoms was 8 months.
CONCLUSIONS: Overactive bladder treatment in patients with multiple sclerosis using 100 U Botox intradetrusor injections seems to be effective and safe. Despite slightly impaired detrusor contractility most patients still voided voluntarily without symptoms. Thus, 100 U Botox may be a reasonable treatment option for overactive bladder symptoms in patients with multiple sclerosis who still void voluntarily.
Keywords
Adult, Aged, Botulinum Toxins, Type A/therapeutic use, Female, Humans, Male, Middle Aged, Multiple Sclerosis/complications, Neuromuscular Agents/therapeutic use, Pilot Projects, Urinary Bladder, Overactive/drug therapy, Urinary Bladder, Overactive/etiology, Urinary Catheterization/statistics & numerical data
Pubmed
Web of science
Create date
05/11/2014 12:12
Last modification date
20/08/2019 13:16
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