Impact of Overweight and Obesity on Disease Outcome in the Pediatric Swiss Inflammatory Bowel Disease Cohort.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_317305A3A540
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of Overweight and Obesity on Disease Outcome in the Pediatric Swiss Inflammatory Bowel Disease Cohort.
Journal
JPGN reports
Author(s)
von Graffenried T., Schoepfer A.M., Rossel J.B., Greuter T., Safroneeva E., Godat S., Henchoz S., Vavricka S.R., Sokollik C., Spalinger J., Braegger C.P., Nydegger A.
ISSN
2691-171X (Electronic)
ISSN-L
2691-171X
Publication state
Published
Issued date
05/2022
Peer-reviewed
Oui
Volume
3
Number
2
Pages
e193
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Given the paucity of data, we aimed to assess the impact of obesity on disease activity, complications, and quality of life (QoL) in pediatric inflammatory bowel disease (IBD) patients.
Prospective analysis of pediatric IBD patients. Patients were categorized into 4 groups according to the World Health Organization (WHO) child growth standards: obese, overweight, normal weight, and underweight.
Three hundred twenty-seven pediatric patients were included (146 with Crohn's disease [CD], 181 with ulcerative colitis of whom 13 [4%] were underweight, 272 [83.2%] had normal weight, 22 [6.7%] were overweight, and 20 [6.1%] were obese). Compared with normal weight patients, obese ulcerative colitis had a significantly higher clinical but not biological disease activity nor severity. Compared with normal weight patients, overweight/obese CD patients did not have higher clinical or biological disease activity nor severity. Perianal abscesses and surgery for this purpose were more frequently observed in overweight/obese CD patients compared with normal weight controls. Overweight/obese IBD patients were similarly hospitalized in the last 12 months compared with normal weight controls.
Prevalence of overweight/obesity was 12.8% in pediatric IBD patients. Obesity was not associated with a decrease in disease remission rates nor an increase in the risk of complicated disease progression in IBD pediatric patients, except for the occurrence of perianal abscesses and related surgery in CD patients.
Keywords
Crohn’s disease, body mass index, disease activity, quality of life, ulcerative colitis
Pubmed
Open Access
Yes
Create date
24/05/2023 13:10
Last modification date
23/01/2024 8:22
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