Research participant perceptions of personal utility in disclosure of individual research results from genomic analysis

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State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_3170B2E6DB83
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Research participant perceptions of personal utility in disclosure of individual research results from genomic analysis
Journal
Journal of Community Genetics
Author(s)
Bogaert Brenda, Crevier Marie-Josée, Roth Cindy, Jox Ralf J., Barazzetti Gaia
ISSN
1868-6001
ISSN-L
1868-310X
Publication state
Published
Issued date
18/09/2024
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
This article elaborates research participant perspectives on the communication of individual research results from genomic analyses. While most analyses focus on how to communicate results from the perspectives of clinicians or researchers, there is insufficient data on user perspectives and how this information may be used, valued, and interpreted by patients and their families. The concept of personal utility, which considers factors related to quality of life, including on how information may impact the person's future decisions, has been shown to be particularly relevant to understand research participant perspectives and to move beyond clinical and analytic utility factors such as mortality and morbidity. This article draws from qualitative research of research participants awaiting genomic results in the case of sudden cardiac death. Our results show perspectives of personal utility in communication of genomic results, including cognitive, behavioral, and affective outcomes. Cognitive outcomes include gain of information, improved knowledge of etiology and inheritance characteristics, and curiosity for what might be found. Behavioral outcomes include being able to plan life decisions, while affective outcomes include various coping strategies used. We will also discuss the value of knowing negative results and incidental findings from the research participant's perspective. This contribution gives suggestions on best practices to guide genome analysis returns, including incorporating participant wishes on individualized communication at the consent stage; developing relational autonomy approaches; and engaging them throughout the research trajectory.
Pubmed
Open Access
Yes
Funding(s)
University of Lausanne
Create date
18/09/2024 14:41
Last modification date
03/10/2024 7:05
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