Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.

Details

Serval ID
serval:BIB_31699
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.
Journal
Journal of Immunology
Author(s)
Zippelius A., Bioley G., Le Gal F.A., Rufer N., Brandes M., Batard P., De Smedt M., Plum J., Speiser D.E., Cerottini J.C., Dietrich P.Y., Romero P., Pittet M.J.
ISSN
0022-1767[print], 0022-1767[linking]
Publication state
Published
Issued date
2004
Volume
172
Number
5
Pages
2773-2777
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
Functionally naive CD8 T cells in peripheral blood from adult humans can be fully described by their CD45RA(bright)CCR7(+)CD62L(+) cell surface phenotype. Cord blood lymphocytes, from healthy newborns, are homogenously functionally naive. Accordingly, the majority of cord blood CD8 T cells express the same pattern of cell surface molecules. Unexpectedly, however, a significant fraction of cord blood CD8 T cells express neither CCR7 nor CD62L. Yet these cells remain functionally naive as they contain high levels of TCR excision circles, have long telomeres, display highly polyclonal TCRs, and do not exhibit immediate effector functions. In addition, these CD8 T cells already represent a significant fraction of the mature naive CD8 single-positive thymocyte repertoire and may selectively express the cutaneous lymphocyte Ag. We suggest that CD8 single-positive thymocytes comprise two pools of naive precursors that exhibit distinct homing properties. Once seeded in the periphery, naive CCR7(+)CD62L(+) CD8 T cells patrol secondary lymphoid organs, whereas naive CCR7(-)CD62L(-) CD8 T cells selectively migrate to peripheral tissues such as skin.
Keywords
CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/immunology, Cell Division/immunology, Cell Movement/immunology, Child, Child, Preschool, Fetal Blood/cytology, Fetal Blood/immunology, Humans, Immunophenotyping, Infant, Infant, Newborn, Interphase/immunology, Receptors, Antigen, T-Cell, alpha-beta/biosynthesis, Receptors, CCR7, Receptors, Chemokine/biosynthesis, Receptors, Chemokine/blood, Skin/cytology, Skin/immunology, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism, Thymus Gland/cytology, Thymus Gland/immunology
Pubmed
Web of science
Create date
19/11/2007 12:30
Last modification date
20/08/2019 13:16
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