Does the Immunocompetent Status of Cancer Patients Have an Impact on Therapeutic DC Vaccination Strategies?

Details

Serval ID
serval:BIB_3145728F3A3C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Does the Immunocompetent Status of Cancer Patients Have an Impact on Therapeutic DC Vaccination Strategies?
Journal
Vaccines
Author(s)
Martin Lluesma S., Graciotti M., Chiang C.L., Kandalaft L.E.
ISSN
2076-393X (Print)
ISSN-L
2076-393X
Publication state
Published
Issued date
23/11/2018
Peer-reviewed
Oui
Volume
6
Number
4
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Although different types of therapeutic vaccines against established cancerous lesions in various indications have been developed since the 1990s, their clinical benefit is still very limited. This observed lack of effectiveness in cancer eradication may be partially due to the often deficient immunocompetent status of cancer patients, which may facilitate tumor development by different mechanisms, including immune evasion. The most frequently used cellular vehicle in clinical trials are dendritic cells (DCs), thanks to their crucial role in initiating and directing immune responses. Viable vaccination options using DCs are available, with a positive toxicity profile. For these reasons, despite their limited therapeutic outcomes, DC vaccination is currently considered an additional immunotherapeutic option that still needs to be further explored. In this review, we propose potential actions aimed at improving DC vaccine efficacy by counteracting the detrimental mechanisms recognized to date and implicated in establishing a poor immunocompetent status in cancer patients.
Keywords
DC vaccine, cancer, immunotherapy
Pubmed
Web of science
Open Access
Yes
Create date
04/01/2019 14:24
Last modification date
20/08/2019 13:16
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